Mass spectrometry (MS)-based proteomics and its application in biology
Graduate School of Health and Medical Sciences at University of Copenhagen
This course is free of charge for PhD students at Danish universities (except Copenhagen Business School), and for PhD Students from NorDoc member faculties. All other participants must pay the course fee.
Anyone can apply for the course, but if you are not a PhD student at a Danish university, you will be placed on the waiting list until enrollment deadline. This also applies to PhD students from NorDoc member faculties. After the enrollment deadline, available seats will be allocated to applicants on the waiting list.
Learning objectives
A student who has met the objectives of the course will be able to:
1. Gain insights into major high-end proteomics technologies and workflows
2. Design quantitative proteomics experiments to address questions in biology
3. Analyze mass spectrometric data of peptides and proteins
4. Understand in which biological applications that quantitative proteomics can be applied
5. Gain insights into computational proteomics tools
Content
This course will take you through the basics about proteomics including MS technologies (orbitrap instrumentation and fragmentation mechanisms for peptide sequencing), quantitative proteomics (SILAC, TMT, and label free), proteomics sample preparation methods, computational proteomics (software and analysis strategies). Furthermore the course will give an overview of applications of quantitative proteomics in biology including large-scale proteome mapping of model organisms, epigenetics and proteomics, in vivo-SILAC, PTMs, paleoproteomics, organellar proteomics, and protein-protein interactions.
Participants
Maximum 24 PhD students with interest in proteomics, precision medicine, protein research, cell biology, cell signaling, omics technologies.
Relevance to graduate programmes
The course is relevant to PhD students from the following graduate programmes at the Graduate School of Health and Medical Sciences, UCPH:
Molecular Mechanisms of Disease
All graduate programmes
Language
English
Form
A mixture of lectures, data analysis exercises, presentations by the participating students, and scientific seminars by invited, international speakers. Technical lectures about modern proteomics technologies used to study cellular signaling pathways, protein-protein interactions, and global proteome changes.
Course director
Jesper Velgaard Olsen, Professor, Novo Nordisk Foundation Center for Protein Research (CPR), Faculty of Health and Medical Sciences (SUND), University of Copenhagen (UCPH), jesper.olsen@cpr.ku.dk
Sara Charlotte Buch-Larsen, Assistant Professor, Novo Nordisk Foundation Center for Protein Research (CPR), Faculty of Health and Medical Sciences (SUND), University of Copenhagen (UCPH), sara.larsen@cpr.ku.dk
Teachers
Boris Macek, Professor, University of Tuebingen
Janne Lethiö, Professor, Karolinska Institutet
Jürgen Cox, Group Leader, Max Planck Institute of Biochemistry
Marcus Krüger, Professor, Center for Molecular Medicine Cologne
Matthias Selbach, Professor, Max Delbrück Center
Michiel Vermeulen, Professor, Radbout Universiteit
Richard Scheltema, Professor, University of Liverpool
Shabaz Mohammed, Associate Professor, University of Oxford
Tiziana Bonaldi, Group Leader, European Institute of Oncology, Milan
Blagoy Blagoev, Professor, University of Southern Denmark
Enrico Cappellini, Associate Professor, Globe Institute, University of Copenhagen
Frank Kjeldsen, Professor, University of Southern Denmark
Jens Andersen, Professor, University of Southern Denmark
Michael L. Nielsen, Head of Biolabs and Scientific Projects, Evosep (former Group Leader)
Jesper V. Olsen, Professor, Professor, NNF CPR, University of Copenhagen
Sara C. Buch-Larsen, Assistant Professor, NNF CPR, University of Copenhagen
Dates
November 11th-15th 2024
Course location
Panum, Novo Nordisk Foundation Center for Protein Research, room 6.2.09
Registration
Please register before October 11th 2024.
Expected frequency
Every second year
Seats to PhD students from other Danish universities will be allocated on a first-come, first-served basis and according to the applicable rules.
Applications from other participants will be considered after the last day of enrolment.
Note: All applicants are asked to submit invoice details in case of no-show, late cancellation or obligation to pay the course fee (typically non-PhD students). If you are a PhD student, your participation in the course must be in agreement with your principal supervisor.